Fig. 4

Increased astrogliosis present in GrnKO mice is not present in Lyz-cKO mice. Representative images of GFAP immunoreactivity in the brains of 12-month-old WT, Lyz-cKO, and GrnKO mice are shown for the thalamus (a), CA3 region of the hippocampus (b), cortex (c), and striatum (d). In each case, quantification of the images is given in the right-most panel. For each mouse, 4–6 images per region were measured and averaged to give a single value per animal per region. N = 5 Ctrl, 12 Lyz-cKO, and 4 GrnKO mice. Data represent mean ± SEM. p values were calculated using Tukey’s multiple comparison test after one-way ANOVA