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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Fig. 8

Mild ER stress inhibits proinflammatory cytokine production in primary cultured microglia. a Primary cultured microglia were subjected to LPS and TM and treated with the indicated dosage of 4-PBA. After 24 h of treatment, cell viability was determined using CCK-8. bd The levels of the proinflammatory factors TNF-α, IL-6, and IL-1β were detected by ELISA. The data are representative of three independent experiments. *P < 0.05, **P < 0.01 vs. naïve group. #P < 0.05, ##P < 0.01 vs. LPS treatment group. ^P < 0.05, ^^P < 0.01 vs. TM treatment group. The data are presented as the mean ± SEM

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