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Table 6 Correlation between cytokine levels and ABC subscale 1 (irritability) score

From: MicroRNA expression changes in association with changes in interleukin-1ß/interleukin10 ratios produced by monocytes in autism spectrum disorders: their association with neuropsychiatric symptoms and comorbid conditions (observational study)

Irritability (ABC I)   IL-1ß/IL-10 ratio
Cytokines measureda Simulant High (N = 43) Normal (N = 43) Low (N = 18)
IL-1ß None − 0.0693a − 0.0966 0.5841 (p < 0.05)
  LPS − 0.1675 − 0.2769 − 0.323
  Zymosan − 0.2907 − 0.0977 − 0.6969 (p < 0.01)
  CL097 − 0.0535 − 0.1543 − 0.4646
  ß-lactam − 0.4134 (p < 0.02) − 0.2494 − 0.5575 (p < 0.05)
IL-6 None − 0.1135 0.0348 − 0.0089
  LPS 0.0029 − 0.1326 − 0.6018 (p < 0.05)
  Zymosan − 0.0155 0.1598 − 0.6859 (p < 0.01)
  CL097 − 0.1148 − 0.0457 − 0.7633 (p < 0.005)
  ß-lactam − 0.0524 0.0015 − 0.7307 (p < 0.005)
TNF-α None 0.0672 0.2512 0.8359 (p < 0.005)
  LPS − 0.061 0.3533 (p < 0.05) 0.6903 (p < 0.01)
  Zymosan − 0.0133 0.3491 (p < 0.05) − 0.0376
  CL097 0.0311 0.1123 0.2257
  ß-lactam − 0.0789 0.2143 0.1305
IL-10 None − 0.0072 0.0938 0.4956
  LPS − 0.2519 − 0.2478 0.2102
  Zymosan − 0.1111 − 0.1858 0.1925
  CL097 − 0.0733 − 0.1351 − 0.3031
  ß-lactam − 0.2178 − 0.3277 0.323
  1. aCorrelation coefficient by Spearman’s test between cytokine levels and scores of ABC subscale I (irritability). Stimulants used for cultures are shown in the column 2