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Table 6 Correlation between cytokine levels and ABC subscale 1 (irritability) score

From: MicroRNA expression changes in association with changes in interleukin-1ß/interleukin10 ratios produced by monocytes in autism spectrum disorders: their association with neuropsychiatric symptoms and comorbid conditions (observational study)

Irritability (ABC I)

 

IL-1ß/IL-10 ratio

Cytokines measureda

Simulant

High (N = 43)

Normal (N = 43)

Low (N = 18)

IL-1ß

None

− 0.0693a

− 0.0966

0.5841 (p < 0.05)

 

LPS

− 0.1675

− 0.2769

− 0.323

 

Zymosan

− 0.2907

− 0.0977

− 0.6969 (p < 0.01)

 

CL097

− 0.0535

− 0.1543

− 0.4646

 

ß-lactam

− 0.4134 (p < 0.02)

− 0.2494

− 0.5575 (p < 0.05)

IL-6

None

− 0.1135

0.0348

− 0.0089

 

LPS

0.0029

− 0.1326

− 0.6018 (p < 0.05)

 

Zymosan

− 0.0155

0.1598

− 0.6859 (p < 0.01)

 

CL097

− 0.1148

− 0.0457

− 0.7633 (p < 0.005)

 

ß-lactam

− 0.0524

0.0015

− 0.7307 (p < 0.005)

TNF-α

None

0.0672

0.2512

0.8359 (p < 0.005)

 

LPS

− 0.061

0.3533 (p < 0.05)

0.6903 (p < 0.01)

 

Zymosan

− 0.0133

0.3491 (p < 0.05)

− 0.0376

 

CL097

0.0311

0.1123

0.2257

 

ß-lactam

− 0.0789

0.2143

0.1305

IL-10

None

− 0.0072

0.0938

0.4956

 

LPS

− 0.2519

− 0.2478

0.2102

 

Zymosan

− 0.1111

− 0.1858

0.1925

 

CL097

− 0.0733

− 0.1351

− 0.3031

 

ß-lactam

− 0.2178

− 0.3277

0.323

  1. aCorrelation coefficient by Spearman’s test between cytokine levels and scores of ABC subscale I (irritability). Stimulants used for cultures are shown in the column 2