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Table 8 Summary of clinical features of ASD subjects with high/low IL-1ß/IL-10 ratios vs. ASD subjects with normal ratios

From: MicroRNA expression changes in association with changes in interleukin-1ß/interleukin10 ratios produced by monocytes in autism spectrum disorders: their association with neuropsychiatric symptoms and comorbid conditions (observational study)

Clinical characteristics ASD subjects
IL-1ß/IL-10 ratio
High or low
(N = 43)
ASD subjects
IL-1ß/IL-10 ratio
Normal
(N = 26)
Fisher’s exact test
Age median, year (range)a 12.1 (3.3–27.0) 11.9 (3.8–22)a  
Gender (male/female) 33:10 20:6 1.0
Cognitive skills < 1st % 33/43 (76.7%) 17/26 (65.3%) 0.4055
Social skillsb < 1st % 40/43 (93.0%) 18/26 (69.2%) 0.0154
NFAc 31/43 (72.1%) 11/26 (42.3%) 0.0373
Seizures 7/43 (16.3%) 1/26 (3.8%) 0.243
Asthmad 5/43 (11.6%) 1/26 (3.8%) 0.3978
Allergic rhinitis 7/43 (16.3%) 2/26 (7.7%) 0.4664
Antibody deficiency 8/43 (18.6%) 2/26 (7.7%) 0.2993
  1. aAge entered to the study
  2. bSocial skills were based on school assessment and VABS scores conducted at school or at our clinic
  3. cNon-IgE-mediated food allergy (NFA) and diagnosis of NFA are detailed in the methods section
  4. dNon-ASD controls employed in this study were all developing typically without history of asthma, seizure disorder, or antibody deficiency. Allergic rhinitis is reported in 2 non-ASD controls. Two non-ASD subjects reported a history of NFA, but they were tolerating a regular diet at the time of sample obtainment, following complete resolution of NFA symptoms