Fig. 6
From: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome
Brain uptake and cellular localization of D-Cy5 in WT and Mecp2-null mice. Dendrimer labeled with Cy5 (D-Cy5; magenta) was taken into microglia (Iba1, red) in the pre-symptomatic period (1 week of age) and in the symptomatic period (7 weeks of age). Little-to-no uptake of D-Cy5 was observed in astrocytes (GFAP; green). White arrows indicated D-Cy5 co-localization with Iba+ cells. Cell nuclei were stained with DAPI (blue). Scale bars = 10 or 5 μm