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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

Fig. 4

DMXBA treatment alleviates chronic restraint stress (CRS)-induced depressive-like behaviors. Mice were exposed to CRS for 21 days and treated with vehicle (Veh), DMXBA, or DMXBA plus α-bungarotoxin (α-BGT) beginning on day 10. ac DMXBA treatment increased sucrose consumption in the sucrose preference test (a) and decreased immobility time in the forced swim test (b) and tail suspension test (c). Concurrent treatment with α-BGT reversed these effects. d–h Neither α-BGT nor DMXBA alone had an effect on depressive-like behaviors (df) or motor activity (gh). Con, control group. Data are expressed as mean ± SEM. n = 27 per group; **P < 0.01 vs. control group; ## P < 0.01 vs. CRS 21d + Veh group; + P < 0.05, ++ P < 0.01 vs. CRS 21d + DMXBA group

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