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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Fig. 8

COX-2 immunoreactivity was decreased while HO-1 immunoreactivity was increased in SSO-treated mice at 3 days post-stroke. pMCAo induced a significant increase in the levels of COX-2 immunoreactivity. COX-2 immunoreactivity was significantly reduced in SSO-treated mice compared to vehicle-treated mice (a). Representative images of COX-2 immunoreactivity in the peri-ischemic area of the ipsilateral (b) and contralateral side (c) of vehicle-treated mouse. Panels (d and e) represent the corresponding areas for the SSO treated mouse. HO-1 immunoreactivity was increased in SSO-treated mice when compared to vehicle-treated mice (g). Panels h and i show representative images of HO-1 immunoreactivities in the peri-ischemic ipsilateral and contralateral side of the vehicle-treated mouse, respectively. Panels j and k represent the corresponding areas in the SSO-treated mice, respectively. High magnification insets show the cellular morphology of the staining. Panels f and l show double staining of COX-2 (f) and HO-1 (l) together with markers of microglia/macrophage (CD45), neurons (NeuN), and astrocytes (GFAP) to confirm the cell types expressing these inflammatory mediators. Scale bar = 50 μm. Data are expressed as mean ± SEM. Immunoreactivities were quantified from the total of seven to ten mice per group. **p < 0.01 and ***p < 0.001. IL ipsilateral, CL contralateral

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