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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Fig. 1

AM404 reduces LPS-induced PGE2 release in OHSC, and this effect is mediated by microglial cells. In wild-type OHSC (OHSC WT, white bars) and microglia-depleted OHSC (OHSC LIP-CL, black bars), AM404 was added 30 min before stimulating with LPS and the amount of PGE2 in the culture medium was determined after 24 h using an enzyme immunoassay. Each column and error bar represents the mean ± SEM of four OHSC/group (six slices/well). *p < 0.05, **p < 0.01, and ***p < 0.001 with respect to LPS (one-way ANOVA followed by the Newman-Keuls post-test)

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