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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Fig. 3

Reduction of LPS-induced PGE2 release by AM404 does not involve the CB1 or TRPV1 receptors. Antagonists of the CB1 (AM251) or TRPV1 receptor (Capsazepine) were used before AM404 and LPS treatment in primary rat microglial cells (a). Effects of AM404 in LPS-treated primary TRPV1−/− knockout mice microglia cells (b). ***p < 0.001 with respect to LPS (one-way ANOVA followed by the Newman-Keuls post-test, three new cultures/group)

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