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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Fig. 5

Internalized α-syn oligomers co-localize with lysosomal markers, irrespective of antibody treatment. Co-cultures were exposed to either Cy3-α-syn oligomers or Cy3-oligomers pre-incubated with mAb47. a After 24 h, oligomers were localized in LAMP-1-positive endosomal-lysosomal compartments. b After pre-incubation with mAb47, the levels of intracellular α-syn were very low. However, when the signal was enhanced the Cy3-α-syn still displayed co-localization with LAMP-1 (arrow) (blue = DAPI). Scale bar = 10 μm

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Journal of Neuroinflammation

ISSN: 1742-2094