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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6

Fig. 4

Effect of an additional dose of vitB6 on APE1 protein expression (a) and carbonyl content (b) in the CX/24 h. Western blot images reveal a reduction in the expression of different APE1 forms after vitB6 pre/post supplementation as indicated in the graph (a). Carbonyl content was significantly reduced after an extra dose of vitB6 (b). Each column from carbonyl data expresses the mean percentage (± SEM) relative to control CX/20 h (showed in Fig. 3c). Comparison between columns which show p < 0.05 were significant in Dunn’s post test. Groups: uninfected control animals (CTRL) (n = 3), infected animals (PM) without vitB6 treatment (n = 6), infected animals plus vitB6 treatment (PM/pre sup vitB6) (n = 9), and infected animals plus second dose of vitB6 treatment (PM/pre pos sup vitB6) (n = 5)

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