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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation

Fig. 3

Cellular localization of IL-33 and ST2 in the rat ipsilateral spinal dorsal horn. a Cell type-specific immunolabeling of IL-33 in the ipsilateral spinal dorsal horn tissue shows colocalization of IL-33 immunoreactivity (in red) with NeuN-immunoreactive neurons (in green; panels ac), GFAP-immunoreactive astrocytes (in green; panels df), and olig-2-immunoreactive oligodendrocytes (in green; panels jl), but not with OX-42-immunoreactive microglia (in green; panels gi). The arrows indicate the colocalization of IL-33 with the respective cell markers (in yellow). Bars = 50 μm. b The percentage of the cell types expressing IL-33/cit is presented. c Cell type-specific immunolabeling of ST2 in the ipsilateral spinal dorsal horn tissue shows colocalization of ST2 immunoreactivity (in red) with NeuN-immunoreactive neurons (in green; panels ac), GFAP-immunoreactive astrocytes (in green; panels df), and olig-2-immunoreactive oligodendrocytes (in green; panels jl), but not with OX-42-immunoreactive microglia (in green; panels gi). The arrows indicate the colocalization of ST2 with the respective cell markers (in yellow). Bars = 50 μm. d The percentage of cellular types expressing ST2/cit is presented

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