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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation

Fig. 6

Spinally delivered lentiviral vector LV-shIL-33 reduces the activation of the MAPK and NF-κB pathways in the dorsal spinal cord. a Representative Western blots of the phosphorylation of ERK, p38, JNK, and p65 protein expression in the rat ipsilateral spinal dorsal horn tissue. β-tubulin was used as the loading control. b The results are expressed as a ratio of phospho-protein to the total protein (p-ERK/ERK), and the control was set at 1.0. c The results are expressed as a ratio of phospho-protein to total protein (p-JNK/JNK), and the control was set at 1.0. d The results are expressed as a ratio of phospho-protein to total protein (p-p38/p38), and the control was set at 1.0. e The results are expressed as a ratio of phospho-protein to total protein (p-p65/p65), and the control is set at 1.0. The values are the mean ± SEM (##p < 0.01 versus sham; *p < 0.05 and **p < 0.01 versus the LV-NC group, n = 5 in each group)

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Journal of Neuroinflammation

ISSN: 1742-2094