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Table 2 Significant differences in intracellular cytokine, plasma cytokine, and high-performance liquid chromatography (HPLC) data between the moderate and severe group

From: Distinct cytokine patterns may regulate the severity of neonatal asphyxia—an observational study

  Time Moderate Severe
Intracellular cytokines—cell prevalence data (% of parent population)
 CD4+ IL-1b+/CD4+ 6 h 3.52 (2.13–5.16) 6.77 (3.18–10.26)
 CD4+ IL-1b+ CD49d+/CD4+ IL-1b+ 6 h 6.98 (4.61–9.32) 4.08 (2.86–5.46)
 CD4+ TNF-a + CD49d+/CD4+ TNF-a+ 6 h 6.63 (4.47–13.45) 3.52 (2.12–7.23)
 CD8+ IL-17+/CD8+ 6 h 5.26 (3.89–14.40) 2.63 (1.75–5.18)
 CD4+ FoxP3+/CD4+ 24 h 2.35 (1.96–3.13) 3.02 (2.60–4.13)
 CD4+ TNF-a+ CD49d+/CD4+ TNF-a+ 72 h 4.77 (3.43–7.70) 9.75 (6.31–10.80)
 CD4+ IL-17+/CD4+ 1 week 3.08 (1.80–4.59) 5.13 (3.40–13.76)
Intracellular cytokines—mean fluorescence intensity (MFI) data (arbitrary unit)
 CD8+ IL-17+/CD8+ 24 h 1069 (639–3265) 4187 (1274–6133)
 CD4+ IFN-g+/CD4+ 72 h 455 (150–770) 887 (496–1427)
 CD4+ IL-17+/CD4+ 72 h 939 (566–1674) 1760 (1614–3508)
 CD4+ TNF-a+/CD4+ 1 month 3281 (1752–4326) 4729 (3959–6714)
Plasma cytokines (pg/mL)
 G-CSF 24 h 19.85 (10.87–30.70) 42.74 (22.27–131.3)
 IL-5 72 h 1.37 (0.00–4.69) 0.20 (0.00–0.46)
 IL-13 72 h 2.35 (2.01–3.67) 1.70 (1.40–2.56)
 IL-6 1 week 21.06 (11.89–43.24) 70.25 (33.73–134.1)
 G-CSF 1 week 13.33 (5.52–17.72) 32.90 (16.65–94.76)
HPLC results (uM)
 KYN 1 month 3.62 (2.72–4.47) 2.28 (1.45–3.14)
  1. p < 0.05 for all comparisons