Table 3 Summary of the proposed effects of distinct cytokines on the severity of neonatal asphyxia
From: Distinct cytokine patterns may regulate the severity of neonatal asphyxia—an observational study
Pro-inflammatory | Anti-inflammatory | |
|---|---|---|
Contribution to better outcome | IL-1β: rapid decrease, higher initial prevalence, and extravasation in severe insult G-CSF: rapid decrease in moderate insult, higher plasma levels in severe insult | TGF-β: increased production and extravasation in moderate insult IDO: early compensation up to 1 week |
Contribution to worse outcome | TNF-α: elevated intracellular levels up to 1 month IL-17: high prevalence in severe insult up to 1 month IL-6: higher plasma levels in severe insult at 1 week, decrease in moderate insult by 1 month | Treg: unremarkable difference at 24 h, not upregulated |