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Fig. 16 | Journal of Neuroinflammation

Fig. 16

From: Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Fig. 16

Graphical summary of findings obtained during this study. Inflammatory levels of LPA increased the migratory response of microglia and promoted pro-inflammatory signaling via the LPAR5/PKD axis. Interference with this signaling axis reduced microglial migration, blunted microglial cytotoxicity, and abrogated the expression and secretion of pro-inflammatory mediators (the steps between LPAR5 and PKDs, MAPKs, and AKT activation are not shown since those parts of the pathways were not experimentally addressed during the present study)

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