Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Table 2 Baseline cross-sectional associations between cognitive scores and OS markers/CRP

Cognitive domain	Marker	Unadjusted		Multivariate	p value
Executive domain				β
	CRP	0.24	0.63	0.109	0.86
	CyS	− 0.088	0.27	− 0.11	0.24
	CySS	− 0.013	0.16	− 0.0028	0.81
	GSSG	16.35	< .0001	17.91	< .0001
	GSH	0.18	0.12	0.23	0.095
Memory domain
	CRP	0.14	0.9	0.19	0.88
	CyS	0.13	0.46	0.29	0.14
	CySS	− 0.0047	0.82	0.013	0.63
	GSSG	− 19.17	0.009	− 22.25	0.0035
	GSH	0.020	0.94	− 0.048	0.877
Working memory domain
	CRP	− 2.27	0.0028	− 1.67	0.063
	CyS	− 0.20	0.089	− 0.19	0.14
	CySS	− 0.0079	0.57	0.0091	0.60
	GSSG	− 30.78	< .0001	− 33.67	< .0001
	GSH	− 0.22	0.22	− 0.47	0.020

All models were adjusted for race, age, gender, systolic blood pressure, body mass index, education, statin, and antihypertension medication
β is derived from the regression analyses of the oxidative stress marker vs cognitive function
CRP C-reactive protein, Cys cysteine, CYSS cystine, GSH glutathione, GSSG glutathione disulfide

ISSN: 1742-2094