Fig. 10

The effect of roscovitine on Aβ-induced changes in TNF-α, IL-10 or IL-6 level in hippocampus. Aβ (0.5 nmol) was injected intracerebroventricularly and roscovitine (50 mg/kg b.w.) was administered intraperitoneally. Cytokine level was analysed 3 h after injection by Cytometric Bead Array (CBA). Results are presented as the mean ± SEM from three to four independent experiments. **, ***p < 0.01 and 0.001 compared with the respective control, ^#p < 0.05 compared with the Aβ-treated animals using a one-way ANOVA followed by the Bonferroni test