Fig. 1

Schedule of experimental procedures. a Saline and LPS were administered subcutaneously in WT (C57BL/6J) mice, and white matter was evaluated at PND 12. b Spleen dendritic cells were counted at 6 h, 24 h, 3 days, and 7 days after LPS injection in WT mice. c γδT cells and dendritic cell activation in the spleen and brain were examined at 14 and 48 h after LPS injection in WT mice. d White matter evaluation and behavior tests were carried out at young (PNDs 26–30) and adult (PNDs 56–60) ages after LPS injection in WT, Tcrd ^−/−, and Tcrα ^−/− mice