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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

Fig. 7

Poldip2 mediates MMP and TIMP1 upregulation in ischemic brain. a MMP-2, MMP-9, TIMP1, and TIMP2 mRNAs were measured by quantitative RT-PCR after sham surgery or tMCAO and 24 h reperfusion in ischemic and sham brain hemispheres of Poldip2+/+ and +/− mice. Bar graphs represent means ± SEM from six mice per group normalized to GAPDH. Two-way ANOVA *p < 0.05, **p < 0.01, and ***p < 0.001 vs. Poldip2+/+ sham mice and §p < 0.05 vs. Poldip2+/+ ischemic mice. b Representative gelatin zymography images and quantification of MMP-9 activity from ischemic and sham brain hemispheres in Poldip2+/+ and Poldip2+/− mice. Bar graphs represent means ± SEM (n = 5 mice per group). Two-way ANOVA ***p < 0.001 vs. sham Poldip2+/+ mice §§§p < 0.001 vs. Poldip2+/+ ischemic mice

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