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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

Fig. 8

TNFα partially reverses the effect of Poldip2 depletion. Poldip2+/+ and Poldip2+/− mice subjected to tMCAO received an intraperitoneal injection with or without 5 μg TNFα, immediately after tMCAO, followed by a 24 h reperfusion. Evans blue extravasation was measured as in Fig. 2. Bars represent means ± SEM from five to seven mice per group. Two-way ANOVA *p < 0.05 vs. Poldip2+/+ no TNFα; §p < 0.05 vs. Poldip2+/+ no TNFα; #p < 0.05 vs. Poldip2+/+ with TNFα and & p < 0.05 vs. Poldip2+/− no TNFα

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