Fig. 9From: Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brainPoldip2 mediates hypoxia and reoxygenation-induced astrocyte activation following tMCAO. tMCAO induces hypoxia, thereby upregulating Poldip2 in astrocytes, leading to increased production of cytokines and a late phase breakdown of the blood-brain barrierBack to article page