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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Fig. 6

Pretreatment with donepezil suppressed the production of NO induced by TNFα in rodent microglial cells through the activation of PI3K pathway. a Ten representative traces showing the treatment of 0.1 ng/mL TNFα induced the increase in the DAF-2 fluorescence in rodent microglial cells. b Ten representative traces showing 12 h pretreatment with 5 μM donepezil suppressed the TNFα-induced increase in the DAF-2 fluorescence in rodent microglial cells. c Ten representative traces showing 12 h pretreatment with both 5 μM donepezil and 10 μM LY294002 did not suppress the TNFα-induced increase in the DAF-2 fluorescence in rodent microglial cells. Representative images (15 min after a treatment of TNFα) are shown in insets of a, b, and c. d Bar graphs showing that pretreatment with donepezil suppressed the production of NO induced by TNFα treatment and the PI3K pathway could be important for the donepezil-induced suppression of the NO production in rodent microglial cells

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