Fig. 8
From: Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
Pretreatment with donepezil promoted phagocytic activity of mouse primary microglial cells through the PI3K but not MAPK/ERK pathway. a Representative images showing that pretreatment with donepezil promoted phagocytic activity of mouse primary microglial cells through the PI3K but not MAPK/ERK pathway. Images shows bright field (left), FITC (middle) and Overlay (right), respectively. b Bar graphs showing that pretreatment of 5 μM donepezil for 12 h enhanced the phagocytic activity of mouse primary microglial cells to about 105% control. In addition, pretreatment with donepezil and LY294002 (10 μM) but not PD98059 (10 μM) for 12 h significantly suppressed the donepezil-induced promotion of phagocytic activity