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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Fig. 5

P2Y12R expression is downregulated on activated microglia in EAE at the peak of the disease. P2Y12R and CD11b double staining on EAE tissues from the peak of the disease showing a highly infiltrated and inflamed area, and a less inflamed area (a). Higher magnification images of P2Y12R and CD11b staining showing a reduction of P2Y12R expression on microglia in the high inflamed area compared the less inflamed area (b). Fluorescence quantification of CD11b (c) and P2Y12R (d) showing a significant increase in CD11b expression and a significant decrease of P2Y12R expression in the highly inflamed area compared to the less inflamed area. Each circle and square represents one drawn region of interest (ROI) and represents tissues from two different rats. Different groups were compared using the Student t test, (one asterisk) p < 0.05, (three asterisks) p < 0.0001. Blue is nuclear staining with DAPI

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Journal of Neuroinflammation

ISSN: 1742-2094