Fig. 6

Effects of the IDO inhibitor 1-MT (1, 3, and 9 mg/kg) on the depressive-like behaviors (a, b) and anxiety behaviors (c–f) of BDL animals. Depressive-like behavior test: sucrose preference test (a) and forced swimming test (b); anxiety-like behavior test: marble-burying test (c) and elevated plus maze test (d–f). The time spent in closed arms (d), the time spent in open arms (e), and the number of entries in closed arms (f) assessed by elevated plus maze of BDL animals in different days (0, 7, 14, 21, and 28 days) after surgery. Data are expressed as mean ± SEM (n = 8). *p < 0.05, **p < 0.01, and ***p < 0.001, when compared to the sham group; ^#p < 0.05 and ^##p < 0.01, when compared to the BDL group