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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

Fig. 7

Effects of the IDO inhibitor 1-MT (1, 3, and 9 mg/kg) on memory deficits (a, b) and locomotor activity (c) induced by BDL in rats. Chronic treatment with 1-MT improves learning and memory behaviors in the Morris water maze task during the 1-h (a1, a2) or 24-h (b1, b2) test trials. Locomotor activity was assessed by the total number of counts recorded for 10 min in BDL animals in different days (0, 7, 14, 21, and 28 days) after surgery. Data are expressed as mean ± SEM (n = 8). **p < 0.01 and ***p < 0.001, when compared to the sham group; ##p < 0.01, when compared to the BDL group

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Journal of Neuroinflammation

ISSN: 1742-2094