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Table 1 Liver function tests in sham and BDL rats

From: Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

  Sham (0 day) BDL
7 days 14 days 21 days 28 days
ALP (IU/L) 112.4 ± 7.2 217.4 ± 9.1* 274.2 ± 10.2** 289.4 ± 11.2** 327.5 ± 12.8**
ALT (IU/L) 42.5 ± 4.3 79.4 ± 5.2* 91.5 ± 6.4* 97.5 ± 7.4** 110.7 ± 8.7**
AST (IU/L) 120.5 ± 10.1 227.7 ± 11.1* 257.5 ± 12.5* 268.4 ± 11.4* 294.5 ± 15.4**
Ammonia (μmol/L) 21.4 ± 3.2 68.1 ± 5.2* 134.7 ± 8.7** 157.8 ± 9.1** 187.4 ± 10.2***
Total bilirubin (mg/dL) 0.41 ± 0.01 2.5 ± 0.1* 4.6 ± 0.15** 5.2 ± 0.13** 5.9 ± 0.31***
Direct bilirubin (mg/dL) 0.20 ± 0.01 1.4 ± 0.1* 2.1 ± 0.12** 2.4 ± 0.14** 2.7 ± 0.21***
Indirect bilirubin (mg/dL) 0.18 ± 0.02 1.1 ± 0.1* 2.2 ± 0.13** 2.3 ± 0.15** 2.4 ± 0.18**
  1. The values are expressed as mean ± SEM (n = 6)
  2. ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase
  3. *p < 0.05; **p < 0.01; ***p < 0.001, vs. the sham group