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Table 1 Liver function tests in sham and BDL rats

From: Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

 

Sham (0 day)

BDL

7 days

14 days

21 days

28 days

ALP (IU/L)

112.4 ± 7.2

217.4 ± 9.1*

274.2 ± 10.2**

289.4 ± 11.2**

327.5 ± 12.8**

ALT (IU/L)

42.5 ± 4.3

79.4 ± 5.2*

91.5 ± 6.4*

97.5 ± 7.4**

110.7 ± 8.7**

AST (IU/L)

120.5 ± 10.1

227.7 ± 11.1*

257.5 ± 12.5*

268.4 ± 11.4*

294.5 ± 15.4**

Ammonia (μmol/L)

21.4 ± 3.2

68.1 ± 5.2*

134.7 ± 8.7**

157.8 ± 9.1**

187.4 ± 10.2***

Total bilirubin (mg/dL)

0.41 ± 0.01

2.5 ± 0.1*

4.6 ± 0.15**

5.2 ± 0.13**

5.9 ± 0.31***

Direct bilirubin (mg/dL)

0.20 ± 0.01

1.4 ± 0.1*

2.1 ± 0.12**

2.4 ± 0.14**

2.7 ± 0.21***

Indirect bilirubin (mg/dL)

0.18 ± 0.02

1.1 ± 0.1*

2.2 ± 0.13**

2.3 ± 0.15**

2.4 ± 0.18**

  1. The values are expressed as mean ± SEM (n = 6)
  2. ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase
  3. *p < 0.05; **p < 0.01; ***p < 0.001, vs. the sham group
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Journal of Neuroinflammation

ISSN: 1742-2094