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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

Fig. 9

I.c.v. infusion of peripheral LPS-exosomes provoked dramatic microglial activation and moderate astrocytic activation. a Representative photomicrographs of the immunofluorescent staining in the brain sections from Saline-Exo ICV- and 5LPS24h-Exo ICV-treated mice. Anti-Iba1 antibody for microglia (red) and anti-GFAP antibodies for astrocytes (green) and DAPI for nuclei (blue). Scale bar, 50 μm. The white-dotted boxes are zoom-in views of the corresponding photomicrographs, scale bar 5 μm. b, c Quantification of the relative immunofluorescent intensity of Iba1 (b) and GFAP (c). n = 3 per group. Data represent mean ± SEM; *P < 0.05 and ***P < 0.001

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