Fig. 4
Central levels of estradiol (E2) content in sham animals or following bilateral brain injury with estrogen receptor antagonism in adult male and female zebra finches (A and B). Treatment with an ER-α or ER-β antagonist during brain injury results in robust E2 synthesis compared to sham controls (A and B). However, receptor antagonism decreases downstream signaling (phosphoinositide-3-kinase) compared to control-injured brains. Dashed line represents injured controls (controls set to 1 for fold change calculation). *p < 0.05