Fig. 3

Extent of VZV reactivation correlates with the degree of reprogramming of CSF metabolite profiles. The group with the higher CSF leukocyte count constitutes the enumerator for calculating ratios of mean concentrations (log2, y-axis) and the positive state for calculating AUCs with binary ROC analysis (x-axis). Significance of AUCs was assessed by asymptotic uncorrected P values (expressed by fill color darkness as indicated in the legend within panel a) and by lower bound CI not crossing below 0.5. a Z. segmental vs. controls. Number of metabolites with AUC lower bound CI > 0.5 (CI > 0.5) = 7. b Z. facial vs. controls. (CI > 0.5) = 23. c Z. men_enc vs. controls. (CI > 0.5) = 56. d Z. men_enc vs. ent. men. (CI > 0.5) = 34. e Z. men_enc vs. Z. facial. (CI > 0.5) = 16. f Z. facial vs. Bell’s palsy. (CI > 0.5) = 18. The most pronounced and significant alterations in metabolite concentrations were observed in Z. men_enc, but reprogramming was also evident for Z. facial and, less so, Z. segmental