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Table 3 Comparison of leukocyte count against metabolite biomarkers to detect CNS infection in VZV reactivation

From: Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation

 

Sensitivity

Specificity

PPV

NPV

AUC (95% CI)

P valuea

Leukocyte count

0.80

0.70

0.57

0.88

0.77 (0.64–0.91)

0.003

SM C16:1

0.73

0.77

0.61

0.85

0.81 (9.68–0.94)

0.001

Glycine

0.80

0.70

0.57

0.88

0.78 (0.64–0.93)

0.002

lysoPC a C26:1

0.93

0.62

0.56

0.95

0.79 (0.66–0.93)

0.002

PC ae C34:0

0.53

1.00

1.00

0.80

0.84 (0.71–0.97)

< 0.0001

  1. Values are based on binary comparison of Z. meningoencephalitis vs. the pool of Z. facial and Z. segmental. The metabolite biomarkers correspond to the four best internally validated metabolites (Fig. 4, Table 2)
  2. AUC area under the receiver operating characteristic curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, PC phosphatidylcholine, SM sphingomyelin
  3. aUncorrected asymptotic P values