Fig. 4
Ex vivo (a) and in vivo (b) distribution of 18F-VC701 in several regions of the central nervous system, in control and EAE mice. Regional distribution data are expressed as tissue to plasma ratios measured ex vivo at 14 (a) and 30 (b) days post-immunization. Regional distribution measured in vivo with PET at 14 days after immunization are expressed as tissue to muscle ratio (c); data are calculated as mean ± SD value; test T, *p < 0.05 vs controls. Representative PET images from the spinal cord of an EAE mouse with clinical score 2 at 14 days after immunization and healthy control mice injected with 18F-VC701 are shown (d)