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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: 18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

Fig. 6

In vivo PET and MRI images representative of a healthy control and one of the EAE mouse (clinical score at 14 d.p.i. corresponding to 2 and 2.5 at 28 d.p.i.) evaluated at 14 days post-immunization. a 18F-VC701 PET and MRI co-registered coronal images of a healthy control; b 18F-VC701 PET and MRI co-registered coronal images from a EAE mice. c Corresponding MRI post-gadolinium T1-weighted (post-Gd T1-w) and T2-weighted (T2-w) images of the animal shown in b. Damaged brain areas are indicated by arrows. Some of these areas are overlapped in both PET and MRI (left hippocampus, white arrow); others are evident only in PET (bilateral hippocampi, red arrows) or in post-contrast MRI (yellow arrow) images. In the ventral part of coronal images of both control and EAE animals is present a marked region of radioactivity uptake deriving from non-specific accumulation of the tracer in extra-cerebral regions

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