18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

Table 1 Table summarizing lesions detected by visual inspection of co-registered brain images of the four EAE mice studied with PET/MRI performed at 14 days post-immunization

EAE lesion localization	EAE lesion detected by T2w MRI	EAE lesion detected by T1/Gd MRI	EAE lesion detected by ^F18VC-701 PET
Periventricular white matter	4/4 +	4/4 +	0/4 +
Thalamus	1/4 +	1/4 +	0/4 +
Cortex	1/4 +	1/4 +	3/4 +
Striatum	2/4 +	2/4 +	3/4 +
Hypothalamus	2/4 +	2/4 +	2/4 +
Hippocampus	3/4 +	3/4 +	3/4 +
Corpus callosum	2/4 +	2/4 +	2/4 +
Periaqueductal gray matter	1/4 +	1/4 +	1/4 +
Midbrain	3/4 +	3/4 +	3/4 +
Pons	3/4 +	3/4 +	4/4 +
Cerebellum	1/4 +	1/4 +	4/4 +

The table indicates overlapping lesion in this two different imaging modalities on acute phase of the disease; +: detected
T1/Gd T1-weighted image with gadolinium contrast agent, T2w T2-weighted MRI, PET imaging with ¹⁸F-VC701 tracer

ISSN: 1742-2094