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Table 1 Table summarizing lesions detected by visual inspection of co-registered brain images of the four EAE mice studied with PET/MRI performed at 14 days post-immunization

From: 18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

EAE lesion localization EAE lesion detected by T2w MRI EAE lesion detected by T1/Gd MRI EAE lesion detected by F18VC-701 PET
Periventricular white matter 4/4 + 4/4 + 0/4 +
Thalamus 1/4 + 1/4 + 0/4 +
Cortex 1/4 + 1/4 + 3/4 +
Striatum 2/4 + 2/4 + 3/4 +
Hypothalamus 2/4 + 2/4 + 2/4 +
Hippocampus 3/4 + 3/4 + 3/4 +
Corpus callosum 2/4 + 2/4 + 2/4 +
Periaqueductal gray matter 1/4 + 1/4 + 1/4 +
Midbrain 3/4 + 3/4 + 3/4 +
Pons 3/4 + 3/4 + 4/4 +
Cerebellum 1/4 + 1/4 + 4/4 +
  1. The table indicates overlapping lesion in this two different imaging modalities on acute phase of the disease; +: detected
  2. T1/Gd T1-weighted image with gadolinium contrast agent, T2w T2-weighted MRI, PET imaging with 18F-VC701 tracer