Fig. 6
From: Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
Effect of curcumin on neuronal excitability in nodose ganglion neurons. The vagal nodose ganglion neurons were obtained from adult rats, and electrophysiological recording was performed from 12 to 48 h. The membrane potential was held at − 65 mV, and action potentials were generated by injecting current. a Representative action potentials recorded before (control) and 5 min after treatment of curcumin (Cur, 10 and 30 μM). b, c Summary of Cur (10 and 30 μM) induced changes in rheobase, spike frequency, first spike latency, membrane potential, and input resistance in nodose ganglion neurons. Data were shown as means ± S.E.M. for each group (n = 12–15). *p < 0.05, **p < 0.01 vs. control group