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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”

Fig. 9

Effect of curcumin on neuronal excitability is mediated by α7 nAChR in nodose ganglion neurons. The vagal nodose ganglion neurons were obtained from adult rats, and electrophysiological recording was performed from 12 to 48 h. The membrane potential was held at − 65 mV, and action potentials were generated by injecting current. Curcumin (Cur, 10 μM) induced modulation of neuronal excitability before and 5 min after bath application of two selective α7 nAChR antagonists α-bungarotoxin (α-BTX, 10 nM) and methyllycaconitine citrate (MLA, 10 nM), respectively, were recorded. a, c Representative action potentials. b, d Summary of changes in rheobase, spike frequency, first spike latency, membrane potential, and input resistance in nodose ganglion neurons. Data were shown as means ± S.E.M. for each group (n = 5–9)

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