Fig. 6

Clustering of MS brain samples and discriminating power of artificial factors derived from gene expression data of meningeal infiltrates. The dendrogram of MS cases based on gene expression data of meningeal infiltrates is shown in a. Cluster analysis was carried out on gene expression data of 36 microdissected samples using the average linkage method with the Euclidean distance measure. Panel b shows that factor 1, but not factors 2 to 4, discriminates cluster 1 (n = 4) and cluster 2 (n = 4). Statistically significant differences were assessed by Mann–Whitney test. Each dot represents the mean factor score value for each MS case; the line marks the median value. n.s. not significant