Table 2 Expression level and prevalence of cellular genes in laser-cut MS brain immune infiltrates

CD4

0.18 ± 0.13 ^a

100%

BAFF

0.038 ± 0.042

96%

IRF7

0.08 ± 0.1

96%

CD8A

2.68 ± 3.65

100%

IL2

0.004 ± 0.009

67%

IFNαR1

0.0087 ± 0.0094

72%

CD20

1.64 ± 2.62

100%

IL4

0.0001 ± 0.0004

11%

Usp18

0.005 ± 0.011

68%

CD138

0.11 ± 0.15

93%

IL9

0.000001 ± 0.000006

1.3%

MXA

0.54 ± 0.62

99%

BCMA

0.016 ± 0.021

87%

IL17A

0.000002 ± 0.000015

1.3%

OAS1

0.08 ± 0.1

100%

NKp46

0.007 ± 0.011

65%

IL22

0.00003 ± 0.00023

3%

IRF8

0.63 ± 0.9

99%

CD56

0.07 ± 0.09

96%

LTα

0.03 ± 0.05

75%

MMP9

0.87 ± 1.33

95%

CD68

1.41 ± 1.34

100%

LTβ

0.11 ± 0.17

99%

COX2

0.08 ± 0.12

95%

CD1a

0.0002 ± 0.0009

20%

TNF

0.05 ± 0.16

84%

iNOS

0.001 ± 0.005

20%

BDCA2

0.0008 ± 0.0024

12%

IL1β

0.07 ± 0.17

83%

CCL2

0.06 ± 0.07

100%

TBX21

0.20 ± 0.29

96%

IL6

0.05 ± 0.08

70%

CCL5

5.66 ± 8.60

100%

EOMES

0.17 ± 0.18

100%

IL10

0.07 ± 0.26

91%

CCL19

5.45 ± 8.23

89%

RORC

0.001 ± 0.003

36%

IL15

0.037 ± 0.041

96%

CCL20

0.004 ± 0.011

43%

FoxP3

0.08 ± 0.15

85%

IL18

0.02 ± 0.05

89%

CCL21

0.10 ± 0.15

85%

CD69

0.27 ± 0.44

100%

p19

0.01 ± 0.02

68%

CXCL10

0.29 ± 0.51

89%

CD161

0.21 ± 0.18

99%

p28

0.01 ± 0.03

36%

CXCL12

0.89 ± 1.06

100%

CD160

0.003 ± 0.008

44%

p35

0.10 ± 0.12

91%

CXCL13

0.22 ± 0.44

84%

Perforin

0.15 ± 0.21

99%

p40

0.006 ± 0.014

55%

CCR5

1.08 ± 2.60

100%

Granzyme A

0.32 ± 0.42

100%

EBI3

0.055 ± 0.049

93%

CCR6

0.05 ± 0.3

81%

Granzyme B

0.01 ± 0.03

51%

GM-CSF

0.0003 ± 0.0009

15%

CXCR3

0.04 ± 0.15

85%

MHC class II

2.83 ± 2.29

100%

IFNβ

0.28 ± 1.43

91%

CXCR5

0.37 ± 1.37

97%

CD86

0.019 ± 0.015

96%

IFNγ

0.01 ± 0.02

68%

RIG1

0.93 ± 1.00

100%

BCL6

1.44 ± 1.78

100%

IL28A

0.00003 ± 0.0002

4%

TLR3

0.005 ± 0.007

64%

CD10

0.003 ± 0.006

45%

IL29

Undetectable

0%

TLR9

0.010 ± 0.013

81%

AID

0.004 ± 0.011

26%

IRF3

1.18 ± 1.55

100%

Ki67

0.065 ± 0.073

83%