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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats

Fig. 5

Hypercapnia aggravates apoptosis of hippocampal neurons of hypoxemic rats (n = 4). a The immunoreactive bands of Bcl-2 (26 kDa), Bax (20 kDa), and GAPDH (36 kDa). b, c There are significant interaction effects between hypercapnia treatment and hypoxia treatment (Bcl-2: P < 0.01; Bax: P < 0.05). d Simple effects analyses show that the protein expression levels of Bcl-2 and Bax in hypercapnia group have no significant difference compared with S group (ns P > 0.05). The protein expression levels of Bcl-2 in hypoxemia group are significantly decreased compared with S group (**P < 0.01). HH group has the lowest levels of the protein in comparison with hypercapnia group (**P < 0.01) and hypoxemia group (**P < 0.01). In contrast, a significant increase in Bax expression is observed in hypoxemia group compared with S group (**P < 0.01). The levels of Bax expression in HH group is the highest as compared to hypercapnia group (**P < 0.01) and hypoxemia group (**P < 0.01). S group sham-operated group, HH group hypercapnia + hypoxemia group. The concentrations of CO2 and O2 in the air are 0.03 and 21%, respectively

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