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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Fig. 4

Effects of P.gingivalis-LPS on spatial memory and trajectories in the Morris water maze (MWM) test. The platform was removed on the sixth day, and the distance traveled in the target quadrant was compared between the groups. The following parameters were assessed: percentage of the distance covered in the target quadrant (a), percentage of time spent in the target quadrant (b), and number of platform crossings in the target quadrant (c). The percentage of distance, percentage of time, and number of platform crossings in the target quadrant were significantly reduced by P.gingivalis-LPS. The typical trajectories of the P.gingivalis-LPS group approximated the arc of a circle, without any crossings over the original platform (d). Data are presented as mean ± SEM; **p < 0.01, ***p < 0.001, compared to the control group; ##p < 0.01, compared to the P.gingivalis-LPS group

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