Fig. 7

Role of p65/NF-κB pathways in IL-1RA-PEP-mediated effects on blood-brain barrier (BBB) disruption. a After the JSH-23 inhibitor was administered, expression levels of ZO-1, MMP-9, angiopoietin-1, and VEGF were analyzed by western blot in the different groups. b–e The gray value of the band was scanned by optical densitometry, and the ratio value was statistically analyzed. Data are shown as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 compared to the vehicle group without JSH-23; #P < 0.05, ##P < 0.01 compared to the IL-1RA-PEP group without JSH-23; n = 4 per group, based on one-way ANOVA with Bonferroni correction