Fig. 2
From: Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade
PBMC gene expression signatures before and after anakinra treatment. Gene expression was quantified using the AmpliSeq Transcriptome kit and the Ion Torrent S5 system as described. Heatmaps show hierarchical clustering of normalized log-2 RPKM from patient PBMC as well as three pediatric control samples. a Heatmap showing genes with > 2-fold difference between pre-treatment sample and mean of control samples. b Heatmap showing genes associated with autoinflammatory interferonopathies, as determined in [6]. c Heatmap showing immune response genes associated with the IL-1-driven autoinflammatory disorder CAPS [18]