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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

Fig. 5

Involvement of caspase-1 activation in UCB-induced cytokine release. a The release of IL-1β and IL-18 at different time points in the cultured rat astrocytes. IL-1β and IL-18 secretion peaked at 12 and 6 h, respectively, after UCB administration. **p < 0.01, versus the control group (0 h) using a two-tailed Student’s t test with Dunnett’s test. The levels of IL-1β (b) and IL-18 (c) were dramatically decreased in the VX-765 group compared with the control group. **p < 0.01, versus the control group; #p < 0.05, versus the UCB group; ##p < 0.01, versus the UCB group using one-way ANOVA with Bonferroni’s post hoc test. Three independent experiments were performed in duplicate. Error bars, SD

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