Fig. 3
From: Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice
Pro-inflammatory cytokines mRNA levels are decreased in trovafloxacin-treated CCI mice. RNA was isolated from ipsilateral cortex from sham and CCI-injured mice treated with vehicle or trovafloxacin (TVX). Gene expression levels for a IL-1β, b TNF-α, and c IL-6 were measured at 1 and 6 days post-injury by qPCR. Values are expressed as mean fold change (± SEM) relative to sham (n = 5), and GAPDH was used as endogenous control. Linear regression analyses were used to determine statistical significance. (p values calculated for dpi and treatment, for IL-1β, TNF-α, and IL-6 separately). *p < 0.01, CCI 1 dpi vs. CCI 6 dpi, **p < 0.05, CCI vehicle vs. CCI + TVX