Fig. 6

Microglia/macrophage accumulation is reduced in trovafloxacin-treated CCI mice. Mice that received CCI injury where treated with trovafloxacin (TVX) or vehicle and were sacrificed at 6 dpi for histology analysis. a Representative images of CD68 immunoreactivity of brain sections from non-treated or TVX-treated CCI-injured mice at the core of the injury (AP − 1.96 to AP − 2.56). These areas were examined in the same anatomical location for each animal. Scale bar = 0.5 mm. Dotted lines demarcated high-density areas of CD68+ staining. b Correspond to the quantification of high-density areas of CD68+ cells (n = 5 per group). Error bars indicate SE of the mean. Linear regression analysis was performed to analyze statistical differences. (p values calculated for distance from Bregma and treatment). **p < 0.05 CCI vehicle vs. CCI + TVX