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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration

Fig. 2

Microglial inflammatory response was inhibitory to axonal outgrowth and this could be modulated (or improved) by extracellular metallothionein-II (MT). a shows the immunohistochemistry of neurons in the co-culture using the SMI312 antibody. The neurons treated with TNFα has a shorter process (or axon) when compare to vehicle. The addition of MT to the TNFα treatment has restored this inhibitory effect to a similar level as that receiving vehicle treatment (ac). d shows the quantitative measurement of the neurite length relative to the vehicle treatment. (Scale Bar in a = 12 μm) (*p < 0.05 compared to vehicle treatment and TNFα + MT using ANOVA; n = 4 experimental cultures per treatment group; error bars = standard errors of the mean fold difference relative to vehicle treatment)

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