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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

Fig. 1

Time course expression of pIRE1α in brain tissues and Immunofluorescence staining showing co-localization post HI. a Western blot assay for temporal profile of pIRE1α and IRE1α expressions from ipsilateral hemisphere at 0, 3, 6, 12, 24, and 72 h post HI; data are expressed as mean ± SEM, n = 5 per group, per time point. Relative densities have been normalized against the sham group. *P < 0.05 compared with sham group. bd Representative microphotographs of immunofluorescence staining for pIRE1α (red) co-localization on neurons (NeuN, green; b), microglia (Iba-1, green; c), and astrocytes (GFAP, green; d) at 6 h post HI. n = 3 per group, scale bar = 100 μm

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