Fig. 2

STF-083010, an IRE1α inhibitor, reduced brain infarction at 24 and 72 h post HI. a–c Representative photographs of TTC-stained coronal brain sections (a), quantitative analysis of infarct volume (b), and body weight gain (c) with single-dose treatment at 24 h post HI. d–f. Representative photographs of TTC-stained coronal brain sections (d), quantitative analysis of infarct volume (e), and body weight gain (f) with multi-dose treatment at 72 h post HI. Data are represented as mean ± SEM, n = 6 in each group. **P < 0.01 compared with sham group, ^##P < 0.01 compared with HI group, ^#P < 0.05 compared with HI group, ^§§P < 0.01 compared with vehicle+HI group, and ^&P < 0.05 compared with STF-15+HI group. STF: STF-083010, an IRE1α RNase-specific inhibitor. STF-15: STF-083010 (15 μg/pup). STF-45: STF-083010 (45 μg/pup)