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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

Fig. 4

STF-083010 improved long-term neurobehavioral function at 5 and 6 weeks post HI. All animals in the HI group exhibited severe neurobehavioral impairments in the sensorimotor tests (a), foot fault test (b), rotarod test (c), T-maze test (d), and Morris water maze test (eg). STF-083010 treatment significantly improved neurological outcomes in the above tests except for foot fault test (b). Data are expressed as mean ± SEM, n = 8 in sham or vehicle+HI groups and 9 in STF+HI group. **P < 0.01 compared with sham group, *P < 0.01 compared with sham group, ##P < 0.01 compared with vehicle+HI group, #P < 0.05 compared with vehicle+HI group

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